G protein-coupled glutamate receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the G protein-coupled glutamate receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYCT1, SECISBP2L, and AQR, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, G protein-coupled glutamate receptor signaling pathway activity versus MYCT1 in PDAC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MYCT1 →	+0.322	+0.679	.003	<.001	3	3
GBM	SECISBP2L →	+0.334	+0.534	.001	.006	3	3
PDAC	AQR →	+0.213	+0.629	.003	.001	3	3
BRCA	PLGRKT →	-0.450	-0.426	.003	.004	3	3
GBM	C5orf15 →	-0.392	-0.657	<.001	<.001	3	3
BRCA	NDUFA5 →	-0.459	-0.788	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007216 vs MYCT1 — PDAC

Explore this scatter interactively →