G protein-coupled glutamate receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the G protein-coupled glutamate receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNAQ, RPP14, and KLHL18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, G protein-coupled glutamate receptor signaling pathway activity versus GNAQ in OESOPHAGUS (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GNAQ →	+1.129	+1.271	<.001	.007	3	4
STOMACH	RPP14 →	+1.060	+0.334	.003	.002	2	3
LARGE_INTESTINE	KLHL18 →	+1.301	+0.411	<.001	<.001	3	2
LARGE_INTESTINE	NBAS →	+0.658	+0.267	.005	.001	3	2
LARGE_INTESTINE	LETMD1 →	-1.127	-0.550	.001	<.001	3	2
OVARY	DYNLRB1 →	+0.740	+1.188	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007216 vs GNAQ — OESOPHAGUS

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