Glutamate receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Glutamate receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIE1, ETS1-AS1, and RGCC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutamate receptor signaling pathway activity versus TIE1 in CCRCC (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TIE1 →	+0.617	+0.720	.002	.001	3	5
CCRCC	ETS1-AS1 →	+0.732	+0.747	<.001	<.001	3	4
CCRCC	RGCC →	+0.715	+0.911	.001	<.001	3	4
GBM	TEK →	+0.764	+1.020	<.001	<.001	3	4
COAD	MAPK8 →	+0.345	+0.498	<.001	.001	3	4
CCRCC	CD36 →	+0.830	+0.674	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007215 vs TIE1 — CCRCC

Explore this scatter interactively →