Glutamate receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Glutamate receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAPN1, CHMP4B, and UBE2R2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutamate receptor signaling pathway activity versus CAPN1 in LARGE_INTESTINE (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CAPN1 →	+0.855	+0.595	.004	.006	3	8
PANCREAS	CHMP4B →	+0.698	+0.705	.005	.009	3	5
BLOOD_Lymphoma	UBE2R2 →	+0.500	+0.775	.003	.002	3	4
BLOOD_Lymphoma	GALNT18 →	-2.228	-0.970	<.001	.001	3	4
OVARY	B3GNT3 →	+2.707	+0.979	<.001	.007	3	4
OVARY	SH3D19 →	+0.868	+1.125	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007215 vs CAPN1 — LARGE_INTESTINE

Explore this scatter interactively →