Serotonin receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Serotonin receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERPINE2, GOLPH3L, and PPP1R1C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SERPINE2 grouped by Serotonin receptor signaling pathway-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SERPINE2 →	-2.500	-0.358	<.001	.002	3	4
BONE	GOLPH3L →	-0.708	-1.581	.007	<.001	3	4
KIDNEY	PPP1R1C →	+1.639	+1.068	<.001	.002	3	4
OVARY	RNF6 →	-0.388	-0.898	.009	.003	3	3
OVARY	AGO4 →	-0.680	-1.151	.002	<.001	3	3
LUNG_SCLC	ATP2C1 →	-1.016	-0.988	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SERPINE2 by Serotonin receptor signaling pathway activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →