Positive regulation of cytosolic calcium ion concentration

Across TCGA patient cohorts, RNA activity of the Positive regulation of cytosolic calcium ion concentration pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEF2C, SGIP1, and S1PR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cytosolic calcium ion concentration activity versus MEF2C in HNSC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MEF2C →	+0.730	+0.225	<.001	<.001	3	6
BRCA	SGIP1 →	+0.748	+0.699	.001	.001	3	5
GBM	S1PR1 →	+0.800	+1.331	<.001	<.001	3	5
LSCC	VRK1 →	-0.866	-0.782	<.001	.002	3	5
OV	NIT2 →	-0.327	-0.516	.005	.002	3	5
OV	CNIH4 →	-0.559	-0.463	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007204 vs MEF2C — HNSC

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