Phospholipase C-activating G protein-coupled receptor signaling pathway

pathway activity — cross-omics
GO:0007200Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Phospholipase C-activating G protein-coupled receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX23, SSB, and STAB1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phospholipase C-activating G protein-coupled receptor signaling pathway activity versus DDX23 in GBM (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMDDX23 →-0.322-0.048<.001<.001310
LSCCSSB →-0.294-0.039<.001<.00139
GBMSTAB1 →+0.640+0.050<.001<.00139
LSCCUSP39 →-0.379-0.043<.001<.00139
OVEVL →+0.693+0.041<.001<.00139
GBMGGT5 →+0.659+0.050<.001.00139
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007200 vs DDX23 — GBM

Per-sample scatter of Phospholipase C-activating G protein-coupled receptor signaling pathway activity vs DDX23 in GBM.

Explore this scatter interactively →

Exploration