Phospholipase C-activating G protein-coupled receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Phospholipase C-activating G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTAFR, LDHA, and KNTC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phospholipase C-activating G protein-coupled receptor signaling pathway activity versus PTAFR in LSCC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PTAFR →	+0.789	+0.466	<.001	.001	3	5
GBM	LDHA →	-0.645	-0.789	.002	.003	3	5
LSCC	KNTC1 →	-0.634	-0.482	<.001	.001	3	5
PDAC	HNRNPA1L2 →	-0.356	-0.502	.002	.002	3	5
PDAC	C5orf34 →	-0.425	-0.479	<.001	.003	3	5
UCEC	NCAPG2 →	-0.460	-0.833	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007200 vs PTAFR — LSCC

Explore this scatter interactively →