Phospholipase C-activating G protein-coupled receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Phospholipase C-activating G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD151, HRH1, and NABP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phospholipase C-activating G protein-coupled receptor signaling pathway activity versus CD151 in LIVER (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CD151 →	+1.522	+1.112	.005	.009	3	7
SOFT_TISSUE	HRH1 →	+2.606	+1.608	.002	.002	3	7
SOFT_TISSUE	NABP1 →	+3.928	+1.605	<.001	.002	3	7
STOMACH	CAV2 →	+4.852	+1.638	<.001	<.001	3	6
OVARY	PANK1 →	-0.904	-0.894	.004	.008	3	6
OVARY	FOSL1 →	+3.078	+0.840	<.001	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007200 vs CD151 — LIVER

Explore this scatter interactively →