Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC1A2, REPS2, and PCLO, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway activity versus SLC1A2 in GBM (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SLC1A2 →	+1.124	+0.290	.005	<.001	3	3
COAD	REPS2 →	+1.220	+0.354	<.001	<.001	3	3
GBM	PCLO →	+0.993	+0.315	<.001	.005	3	3
PDAC	GPR89P →	+0.940	+0.540	.001	.003	3	2
PDAC	HMGN1P14 →	+0.272	+0.334	.005	.004	3	2
COAD	TSPO →	-0.590	-0.193	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007197 vs SLC1A2 — GBM

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