Adenylate cyclase-inhibiting dopamine receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Adenylate cyclase-inhibiting dopamine receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SUPT16H, BAZ1A, and IPO4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenylate cyclase-inhibiting dopamine receptor signaling pathway activity versus SUPT16H in LSCC (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SUPT16H →	+0.293	+0.090	<.001	<.001	3	7
LSCC	BAZ1A →	+0.410	+0.118	<.001	<.001	3	7
LSCC	IPO4 →	+0.350	+0.097	<.001	<.001	3	7
CCRCC	MTHFD1 →	+0.335	+0.113	<.001	<.001	3	7
HNSC	PLEKHG3 →	+0.318	+0.101	<.001	<.001	3	7
OV	LARP4 →	+1.291	+0.097	.005	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007195 vs SUPT16H — LSCC

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