Adenylate cyclase-activating dopamine receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Adenylate cyclase-activating dopamine receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFC2-KCTD14, CLSPN, and NDUFA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NDUFC2-KCTD14 grouped by Adenylate cyclase-activating dopamine receptor signaling pathway-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	NDUFC2-KCTD14 →	-0.121	-0.122	.001	<.001	3	5
BREAST	CLSPN →	-0.286	-0.181	<.001	.001	3	4
BLOOD_Lymphoma	NDUFA1 →	-0.625	-0.429	.002	.008	3	4
BLOOD_Lymphoma	EPB41L4A →	+0.507	+0.280	.001	.001	3	4
BREAST	CST11 →	+0.151	+0.173	.001	<.001	3	4
BREAST	TMC1 →	-0.207	-0.221	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NDUFC2-KCTD14 by Adenylate cyclase-activating dopamine receptor signaling pathway activity — LIVER

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