Adenylate cyclase-activating G protein-coupled receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Adenylate cyclase-activating G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMELESS, BRCA1, and NEK2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenylate cyclase-activating G protein-coupled receptor signaling pathway activity versus TIMELESS in PDAC (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TIMELESS →	-0.317	-0.370	.005	.007	2	7
LSCC	BRCA1 →	-0.927	-0.708	<.001	<.001	3	6
LSCC	NEK2 →	-0.795	-0.550	.001	.001	3	5
OV	CKAP2 →	-0.898	-0.881	.003	<.001	3	5
LSCC	CLEC1A →	+0.655	+0.697	.001	.001	3	5
GBM	SGIP1 →	+0.513	+0.684	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007189 vs TIMELESS — PDAC

Explore this scatter interactively →