Adenylate cyclase-activating G protein-coupled receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Adenylate cyclase-activating G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM234B, ELAVL1, and RAB9A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenylate cyclase-activating G protein-coupled receptor signaling pathway activity versus FAM234B in LUNG_SCLC (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FAM234B →	-1.234	-0.243	<.001	<.001	3	4
LARGE_INTESTINE	ELAVL1 →	+0.551	+0.221	<.001	.001	3	4
BLOOD_Lymphoma	RAB9A →	+1.633	+0.422	<.001	<.001	3	4
LIVER	GNAI2 →	+1.107	+0.231	<.001	.002	3	4
SOFT_TISSUE	SPECC1 →	+2.698	+0.314	.002	.008	3	4
LUNG_NSCLC_LUAD	TPGS2 →	+0.591	+0.173	.004	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007189 vs FAM234B — LUNG_SCLC

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