Adenylate cyclase-modulating G protein-coupled receptor signaling pathway

pathway activity — cross-omics
GO:0007188Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Adenylate cyclase-modulating G protein-coupled receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMARCA4, BOP1, and DDX27, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenylate cyclase-modulating G protein-coupled receptor signaling pathway activity versus SMARCA4 in GBM (Pearson r = -0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMSMARCA4 →-0.336-0.031<.001<.00139
OVBOP1 →-0.358-0.025.006.00139
LSCCDDX27 →-0.312-0.026<.001<.00139
GBMEFTUD2 →-0.220-0.044<.001<.00139
OVITGA1 →+0.516+0.020<.001<.00139
LSCCNUP93 →-0.181-0.029<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007188 vs SMARCA4 — GBM

Per-sample scatter of Adenylate cyclase-modulating G protein-coupled receptor signaling pathway activity vs SMARCA4 in GBM.

Explore this scatter interactively →

Exploration