Adenylate cyclase-modulating G protein-coupled receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Adenylate cyclase-modulating G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNRIP1, LRRC32, and PTH1R, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenylate cyclase-modulating G protein-coupled receptor signaling pathway activity versus CNRIP1 in OV (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CNRIP1 →	+0.737	+0.636	<.001	<.001	3	9
BRCA	LRRC32 →	+1.110	+0.877	<.001	<.001	3	8
OV	PTH1R →	+0.842	+0.866	.002	<.001	3	8
OV	MFAP4 →	+1.736	+0.931	.002	<.001	3	8
OV	PODN →	+1.288	+0.644	<.001	<.001	3	8
BRCA	ZNF781 →	+0.469	+0.681	.003	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007188 vs CNRIP1 — OV

Explore this scatter interactively →