Adenylate cyclase-modulating G protein-coupled receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Adenylate cyclase-modulating G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IQCN, DHTKD1, and ZNF2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IQCN grouped by Adenylate cyclase-modulating G protein-coupled receptor signaling pathway-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	IQCN →	+0.370	+0.620	.001	.009	2	5
BLOOD_Leukemia	DHTKD1 →	+1.021	+0.220	.002	.007	3	4
OESOPHAGUS	ZNF2 →	+0.619	+0.220	.003	.003	3	4
STOMACH	LIN52 →	+0.774	+0.236	<.001	<.001	3	4
LUNG_NSCLC_LUAD	POLR2K →	-0.523	-0.139	.007	.004	3	3
OESOPHAGUS	PELP1 →	+0.821	+0.230	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IQCN by Adenylate cyclase-modulating G protein-coupled receptor signaling pathway activity — SKIN

Explore this box plot interactively →