"G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"

Across TCGA patient cohorts, RNA activity of the "G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger" pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSR2, DDIT4L, and SPNS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger" activity versus TSR2 in CCRCC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TSR2 →	+0.233	+0.538	<.001	.001	3	4
UCEC	DDIT4L →	+0.893	+0.282	.003	.002	3	3
HNSC	SPNS2 →	+0.757	+0.404	.008	.003	3	3
CCRCC	SLC1A5 →	-0.360	-0.533	.005	.004	3	3
GBM	SLC1A2 →	+1.447	+0.840	<.001	<.001	3	3
GBM	SERINC1 →	+0.590	+0.783	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007187 vs TSR2 — CCRCC

Explore this scatter interactively →