"G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"

Across TCGA pan-cancer cohorts, RNA activity of the "G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger" pathway is associated with patient survival in 17 of 34 cancer lineages. Pathway activity is summarized from the expression of its 56 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher "G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger" pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LGG and ACC, show the opposite pattern, with higher activity associated with better survival.

LGG, ACC, and LIHC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.490	0.336	<.001	51	view →
ACC	DFS	Tertile	All	0.763	0.316	<.001	50	view →
LIHC	OS	Median	III,IV	0.669	0.402	.001	26	view →
STAD	DFS	Quartile	IV	0.105	0.482	.005	24	view →
CESC	OS	Quartile	All	0.380	0.553	.012	20	view →
GBM	OS	Median	All	0.297	0.499	.017	18	view →
READ	OS	Quartile	All	0.304	0.851	.005	17	view →
THYM	DFS	Quartile	II,III,IV	0.728	0.990	.008	16	view →
CHOL	OS	Tertile	II,III,IV	0.080	0.740	.038	12	view →
LUAD	DFS	Quartile	III,IV	0.604	0.252	.019	11	view →
KIRC	DFS	Median	All	0.857	0.741	.007	8	view →
KIRP	DFS	Median	All	0.970	0.817	.020	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

GO:0007187–LGG (DFS)

Open the LGG breakdown →