"G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"

Across TCGA cell cohorts, RNA activity of the "G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger" pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD7, FBH1, and COPRS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD7 grouped by "G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CD7 →	+4.440	+0.956	<.001	.003	3	4
SKIN	FBH1 →	+0.645	+0.911	<.001	.001	3	4
STOMACH	COPRS →	+0.838	+1.305	<.001	.009	3	4
STOMACH	PPIE →	+0.700	+0.808	.004	.006	3	4
LUNG_NSCLC_LUAD	INHBE →	+0.618	+0.338	.007	.005	3	3
LUNG_NSCLC_LUAD	UQCRB →	-0.580	-0.407	.008	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD7 by "G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger" activity — BLOOD_Leukemia

Explore this box plot interactively →