Cell surface receptor protein tyrosine phosphatase signaling pathway

Across TCGA patient cohorts, RNA activity of the Cell surface receptor protein tyrosine phosphatase signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRCH2, PRKAA1, and ST6GAL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell surface receptor protein tyrosine phosphatase signaling pathway activity versus LRCH2 in HNSC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LRCH2 →	+0.532	+0.185	.007	.001	3	5
HNSC	PRKAA1 →	+0.514	+0.206	.002	.006	3	5
HNSC	ST6GAL2 →	+0.944	+0.203	<.001	<.001	3	5
HNSC	IL12A-AS1 →	+0.296	+0.185	.002	.001	3	4
UCEC	MAGI2-AS1 →	+0.788	+0.200	<.001	.003	3	4
UCEC	DDX12P →	-1.020	-0.240	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007185 vs LRCH2 — HNSC

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