Cell surface receptor protein tyrosine phosphatase signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Cell surface receptor protein tyrosine phosphatase signaling pathway pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher Cell surface receptor protein tyrosine phosphatase signaling pathway pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and HNSC, show the opposite pattern, with higher activity associated with better survival.

UCS, UVM, and THCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Quartile	III,IV	0.595	0.160	<.001	28	view →
UVM	DFS	Quartile	All	0.153	0.844	<.001	27	view →
THCA	OS	Tertile	All	0.932	1.000	.003	25	view →
HNSC	DFS	Quartile	III,IV	0.543	0.329	.005	19	view →
STAD	OS	Quartile	IV	0.720	0.150	.008	18	view →
KIRC	DFS	Median	II,III,IV	0.643	0.852	.004	14	view →
READ	DFS	Quartile	All	0.269	0.863	.012	12	view →
PCPG	DFS	Tertile	All	0.977	0.825	.017	9	view →
KICH	DFS	Median	III,IV	1.000	0.430	.022	9	view →
MESO	OS	Tertile	IV	0.358	0.770	.031	9	view →
LUSC	DFS	Median	III,IV	0.417	0.646	.014	8	view →
ACC	OS	Median	IV	0.842	0.244	.001	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0007185–UCS (DFS)

Open the UCS breakdown →