Cell surface receptor protein tyrosine phosphatase signaling pathway

Across TCGA cell cohorts, RNA activity of the Cell surface receptor protein tyrosine phosphatase signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B4GALT2, NFKBIB, and CYB5B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell surface receptor protein tyrosine phosphatase signaling pathway activity versus B4GALT2 in LARGE_INTESTINE (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	B4GALT2 →	+0.757	+1.020	.001	.002	3	4
STOMACH	NFKBIB →	-0.923	-1.224	.005	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	CYB5B →	+1.105	+1.557	.001	<.001	3	3
LARGE_INTESTINE	PEX14 →	+0.685	+1.171	.004	.003	3	3
LARGE_INTESTINE	EIF4E →	+0.822	+1.069	<.001	<.001	2	4
LARGE_INTESTINE	H2AZ1 →	+0.925	+1.069	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007185 vs B4GALT2 — LARGE_INTESTINE

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