Transforming growth factor beta receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Transforming growth factor beta receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS2_S120, VCL, and VCL_S795, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transforming growth factor beta receptor signaling pathway activity versus TNS2_S120 in BRCA (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TNS2_S120 →	+0.512	+0.036	<.001	<.001	3	10
UCEC	VCL →	+0.433	+0.058	<.001	<.001	3	10
LSCC	VCL_S795 →	+0.647	+0.051	<.001	<.001	3	10
OV	DCN →	+1.055	+0.070	<.001	<.001	3	10
CCRCC	LUM →	+0.941	+0.045	<.001	<.001	3	10
OV	NID2 →	+0.641	+0.080	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007179 vs TNS2_S120 — BRCA

Explore this scatter interactively →