Transforming growth factor beta receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Transforming growth factor beta receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHOT2, PATZ1, and CDKL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RHOT2 grouped by Transforming growth factor beta receptor signaling pathway-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RHOT2 →	-0.873	-0.869	<.001	.004	3	4
BREAST	PATZ1 →	-0.955	-0.436	.001	.009	3	3
OVARY	CDKL1 →	-1.767	-0.854	.001	.002	3	3
OVARY	TSC2 →	-0.918	-0.863	.001	.002	2	4
OVARY	SBNO1 →	-0.777	-0.942	.005	.001	3	3
SOFT_TISSUE	TMEM259 →	-0.887	-0.974	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RHOT2 by Transforming growth factor beta receptor signaling pathway activity — SOFT_TISSUE

Explore this box plot interactively →