Activation of transmembrane receptor protein tyrosine kinase activity

Across TCGA patient cohorts, RNA activity of the Activation of transmembrane receptor protein tyrosine kinase activity pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FERMT2, PARVA, and ATXN2L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activation of transmembrane receptor protein tyrosine kinase activity activity versus FERMT2 in COAD (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FERMT2 →	+0.606	+0.045	<.001	<.001	3	5
COAD	PARVA →	+0.375	+0.035	.001	.003	3	5
COAD	ATXN2L →	-0.146	-0.032	.008	.003	3	4
COAD	SVIL_S905 →	+0.587	+0.045	<.001	.001	3	4
COAD	TNS1 →	+0.363	+0.032	.004	.005	3	4
CCRCC	TNS2 →	+0.320	+0.071	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007171 vs FERMT2 — COAD

Explore this scatter interactively →