Activation of transmembrane receptor protein tyrosine kinase activity

Across TCGA pan-cancer cohorts, RNA activity of the Activation of transmembrane receptor protein tyrosine kinase activity pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Activation of transmembrane receptor protein tyrosine kinase activity pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and ACC, show the opposite pattern, with higher activity associated with better survival.

KIRC, ACC, and SKCM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	All	0.725	0.553	<.001	91	view →
ACC	OS	Median	All	0.809	0.451	<.001	80	view →
SKCM	OS	Median	All	0.836	0.731	<.001	42	view →
DLBC	DFS	Quartile	All	0.499	1.000	.004	42	view →
UVM	OS	Tertile	All	0.940	0.505	.002	38	view →
OV	OS	Median	II,III,IV	0.282	0.365	.007	34	view →
COAD	DFS	Median	IV	0.294	0.612	<.001	33	view →
PAAD	DFS	Median	All	0.433	0.292	.012	21	view →
LIHC	OS	Quartile	II,III,IV	0.903	0.487	.002	18	view →
KIRP	OS	Median	II,III,IV	0.895	0.664	.019	17	view →
KICH	DFS	Median	II,III,IV	0.713	0.958	.013	14	view →
STAD	OS	Quartile	All	0.447	0.654	.015	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0007171–KIRC (DFS)

Open the KIRC breakdown →