Activation of transmembrane receptor protein tyrosine kinase activity

Across TCGA cell cohorts, RNA activity of the Activation of transmembrane receptor protein tyrosine kinase activity pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR2H, ZNF639, and PNLIPRP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLR2H grouped by Activation of transmembrane receptor protein tyrosine kinase activity-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	POLR2H →	-0.353	-0.237	<.001	<.001	3	4
SKIN	ZNF639 →	+0.202	+0.247	.001	.007	3	4
BLOOD_Myeloma	PNLIPRP2 →	-0.388	-0.273	.003	<.001	3	3
LUNG_SCLC	CMSS1 →	-0.168	-0.281	.001	.001	3	3
BONE	ECHS1 →	+0.178	+0.315	.001	<.001	3	3
BONE	HOXA4 →	-0.134	-0.331	.007	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLR2H by Activation of transmembrane receptor protein tyrosine kinase activity activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →