Receptor guanylyl cyclase signaling pathway

Across TCGA patient cohorts, RNA activity of the Receptor guanylyl cyclase signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CASC3_S265, EPB41L2_S87, and IWS1_S248, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor guanylyl cyclase signaling pathway activity versus CASC3_S265 in COAD (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CASC3_S265 →	-0.297	-0.032	<.001	.004	3	3
COAD	EPB41L2_S87 →	+0.411	+0.034	.003	.002	3	3
COAD	IWS1_S248 →	-0.549	-0.057	.007	.001	3	3
GBM	ZBTB34_S164 →	-0.838	-0.137	.009	.001	3	3
GBM	CLIP1_T182 →	-0.380	-0.079	.001	.002	3	3
OV	UBXN6 →	+0.197	+0.054	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007168 vs CASC3_S265 — COAD

Explore this scatter interactively →