Establishment of tissue polarity

Across TCGA patient cohorts, RNA activity of the Establishment of tissue polarity pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADGRE5, KLHDC4, and PDCD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of tissue polarity activity versus ADGRE5 in LSCC (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADGRE5 →	-0.711	-0.546	.001	<.001	3	5
HNSC	KLHDC4 →	-0.602	-0.564	<.001	<.001	3	5
BRCA	PDCD1 →	-0.711	-0.283	<.001	.001	3	4
OV	VTRNA1-1 →	+0.461	+0.450	.004	.002	3	4
OV	DEF6 →	-0.635	-0.362	.002	.006	3	4
OV	SIRPG →	-0.586	-0.342	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007164 vs ADGRE5 — LSCC

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