Establishment of tissue polarity

Across TCGA cell cohorts, RNA activity of the Establishment of tissue polarity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LEPROTL1, FLOT2, and PHGR1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LEPROTL1 grouped by Establishment of tissue polarity-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	LEPROTL1 →	+0.841	+0.265	.009	.007	3	3
LUNG_SCLC	FLOT2 →	+0.798	+0.272	.003	.001	3	3
CNS	PHGR1 →	-0.157	-0.459	.001	.005	3	3
LIVER	RBM38 →	+1.114	+0.204	.001	.004	3	3
LIVER	CEBPZOS →	-0.783	-0.213	.007	.002	3	3
PANCREAS	DGAT1 →	+0.998	+0.321	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LEPROTL1 by Establishment of tissue polarity activity — LUNG_SCLC

Explore this box plot interactively →