Establishment of tissue polarity

Across TCGA cell cohorts, RNA activity of the Establishment of tissue polarity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAPPC1, CELSR1, and RAD51D, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of tissue polarity activity versus TRAPPC1 in BLOOD_Leukemia (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TRAPPC1 →	+1.065	+0.207	.009	<.001	3	6
OVARY	CELSR1 →	-1.764	-0.341	<.001	<.001	3	5
CNS	RAD51D →	+0.336	+0.407	.001	.005	3	4
BLOOD_Lymphoma	TNFRSF11A →	+3.136	+0.138	.001	.001	3	4
LUNG_NSCLC_LUSC	H3C8 →	-0.878	-0.489	.009	.001	3	4
PANCREAS	CIB2 →	+1.992	+0.315	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007164 vs TRAPPC1 — BLOOD_Leukemia

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