Establishment or maintenance of cell polarity

Across TCGA cell cohorts, RNA activity of the Establishment or maintenance of cell polarity pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN12, GPR82, and TSC22D4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTPN12 grouped by Establishment or maintenance of cell polarity-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PTPN12 →	+0.229	+0.154	.001	.008	3	7
SKIN	GPR82 →	-0.176	-0.182	.004	<.001	3	6
PANCREAS	TSC22D4 →	+0.178	+0.265	.002	<.001	3	6
KIDNEY	ABCC10 →	-0.214	-0.217	.002	.001	3	5
KIDNEY	CDH11 →	-0.237	-0.220	<.001	<.001	3	5
PANCREAS	CTNNB1 →	-0.577	-0.217	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTPN12 by Establishment or maintenance of cell polarity activity — LARGE_INTESTINE

Explore this box plot interactively →