Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

Across TCGA patient cohorts, RNA activity of the Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC4, CORO1A, and DOCK2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules activity versus RFC4 in LSCC (Pearson r = -0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC4 →	-0.410	-0.056	<.001	<.001	3	9
HNSC	CORO1A →	+0.538	+0.048	<.001	.001	3	9
HNSC	DOCK2 →	+0.519	+0.050	<.001	<.001	3	9
LUAD	NCKAP1L →	+0.429	+0.044	<.001	.002	3	9
UCEC	PLEKHO2 →	+0.414	+0.061	<.001	.001	3	9
OV	ARPC2 →	+0.246	+0.053	.006	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007157 vs RFC4 — LSCC

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