Homophilic cell adhesion via plasma membrane adhesion molecules

Across TCGA patient cohorts, RNA activity of the Homophilic cell adhesion via plasma membrane adhesion molecules pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSMB10, RNF213, and CLSTN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Homophilic cell adhesion via plasma membrane adhesion molecules activity versus PSMB10 in GBM (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PSMB10 →	-0.351	-0.047	.007	.002	3	7
GBM	RNF213 →	-0.334	-0.048	<.001	.001	3	6
LSCC	CLSTN1 →	+0.550	+0.030	<.001	<.001	3	6
HNSC	GALM →	-0.447	-0.054	.001	.001	3	6
PDAC	ATRN →	+0.268	+0.031	<.001	<.001	3	6
LSCC	SEPTIN1 →	-0.594	-0.043	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007156 vs PSMB10 — GBM

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