Female meiotic nuclear division

Across TCGA cell cohorts, RNA activity of the Female meiotic nuclear division pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDC80, SKA1, and SKA3, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Female meiotic nuclear division activity versus NDC80 in BREAST (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NDC80 →	+1.388	+0.113	.001	<.001	3	17
BREAST	SKA1 →	+1.442	+0.156	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	SKA3 →	+1.302	+0.122	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	DBF4 →	+1.045	+0.094	<.001	<.001	3	13
BREAST	STIL →	+1.171	+0.132	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	DSCC1 →	+1.066	+0.094	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007143 vs NDC80 — BREAST

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