Male meiosis I

Across TCGA patient cohorts, RNA activity of the Male meiosis I pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MKI67_S827, CDC20_T70, and CDK1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Male meiosis I activity versus MKI67_S827 in BRCA (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MKI67_S827 →	+1.021	+0.041	<.001	<.001	3	9
UCEC	CDC20_T70 →	+0.889	+0.068	<.001	<.001	3	9
OV	CDK1 →	+0.708	+0.044	<.001	<.001	3	9
LSCC	MCM4_T110 →	+1.137	+0.057	<.001	<.001	3	9
UCEC	MCM5 →	+0.625	+0.068	<.001	<.001	3	9
UCEC	VRK1 →	+0.524	+0.068	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007141 vs MKI67_S827 — BRCA

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