Male meiosis I

Across TCGA patient cohorts, RNA activity of the Male meiosis I pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBAP11, NR2F6, and C16orf89, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Male meiosis I activity versus TUBAP11 in LUAD (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TUBAP11 →	+0.350	+0.563	<.001	.001	3	3
COAD	NR2F6 →	+0.417	+0.677	.002	.001	3	3
GBM	C16orf89 →	-0.718	-0.501	.002	.008	3	3
GBM	MBP →	-1.513	-0.413	<.001	.009	3	3
GBM	LINC00957 →	-0.366	-0.424	.002	.007	3	3
LUAD	KNOP1 →	+0.263	+0.545	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007141 vs TUBAP11 — LUAD

Explore this scatter interactively →