Nuclear migration

Across TCGA patient cohorts, RNA activity of the Nuclear migration pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX17, EP300, and ADNP, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear migration activity versus DDX17 in UVM (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	DDX17 →	+1.154	+0.038	<.001	<.001	3	34
DLBC	EP300 →	+1.409	+0.051	<.001	<.001	3	34
TGCT	ADNP →	+1.034	+0.065	<.001	<.001	3	34
TGCT	SMCHD1 →	+1.448	+0.059	<.001	<.001	3	34
UVM	MIB1 →	+1.211	+0.036	<.001	<.001	3	34
UVM	XIAP →	+1.222	+0.034	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007097 vs DDX17 — UVM

Explore this scatter interactively →