Nuclear migration

Across TCGA patient cohorts, RNA activity of the Nuclear migration pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBA1C, SGCD, and CSRP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear migration activity versus TUBA1C in UCEC (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TUBA1C →	-0.619	-0.121	.004	.001	3	5
LSCC	SGCD →	+0.710	+0.163	<.001	<.001	3	5
BRCA	CSRP1 →	+0.657	+0.157	<.001	.001	3	5
BRCA	LAMB2 →	+0.904	+0.158	.003	.004	3	5
LSCC	STARD13-AS →	+0.437	+0.108	.003	.007	3	5
UCEC	NCAPG →	-0.919	-0.152	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007097 vs TUBA1C — UCEC

Explore this scatter interactively →