Nuclear migration

Across TCGA cell cohorts, RNA activity of the Nuclear migration pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C4B, VPS9D1, and LYAR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear migration activity versus C4B in SOFT_TISSUE (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C4B →	+1.572	+0.135	.004	<.001	3	5
STOMACH	VPS9D1 →	+0.795	+0.152	.008	<.001	3	5
SOFT_TISSUE	LYAR →	-1.136	-0.118	.009	.004	3	4
SOFT_TISSUE	RASA4B →	+1.654	+0.166	.007	<.001	3	4
LUNG_SCLC	TPGS1 →	+1.131	+0.245	.007	.001	3	4
LUNG_NSCLC_LUSC	GNA12 →	+1.222	+0.229	.005	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007097 vs C4B — SOFT_TISSUE

Explore this scatter interactively →