Regulation of exit from mitosis

Across TCGA cell cohorts, RNA activity of the Regulation of exit from mitosis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IER3IP1, ADHFE1, and TRPM7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IER3IP1 grouped by Regulation of exit from mitosis-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	IER3IP1 →	+0.754	+0.268	<.001	.003	3	3
BLOOD_Lymphoma	ADHFE1 →	+0.678	+0.268	.002	.003	3	3
BLOOD_Lymphoma	TRPM7 →	+0.693	+0.268	.005	.003	3	3
URINARY_TRACT	BLZF1 →	+0.424	+0.260	.001	<.001	3	3
URINARY_TRACT	PREX1 →	-2.187	-0.274	.003	.003	3	3
BREAST	CFAP70 →	-0.761	-0.172	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IER3IP1 by Regulation of exit from mitosis activity — BLOOD_Lymphoma

Explore this box plot interactively →