Mitotic G2 DNA damage checkpoint signaling

Across TCGA cell cohorts, RNA activity of the Mitotic G2 DNA damage checkpoint signaling pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXC2, IL15RA, and HECW1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FOXC2 grouped by Mitotic G2 DNA damage checkpoint signaling-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FOXC2 →	+1.654	+0.185	<.001	.004	3	5
LARGE_INTESTINE	IL15RA →	+1.349	+0.166	.005	<.001	3	5
BREAST	HECW1 →	+0.839	+0.135	.002	.001	3	4
BLOOD_Leukemia	PCID2 →	+0.729	+0.228	<.001	.001	3	4
SOFT_TISSUE	UPF3A →	+0.941	+0.208	.001	.005	3	4
BLOOD_Leukemia	UTP14C →	+1.103	+0.296	.004	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FOXC2 by Mitotic G2 DNA damage checkpoint signaling activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →