Regulation of mitotic nuclear division

Across TCGA cell cohorts, RNA activity of the Regulation of mitotic nuclear division pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MELK, SKA3, and RRM1, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitotic nuclear division activity versus MELK in OESOPHAGUS (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MELK →	+1.571	+0.175	<.001	<.001	3	20
OESOPHAGUS	SKA3 →	+1.414	+0.152	<.001	.002	3	20
PANCREAS	RRM1 →	+1.361	+0.129	<.001	<.001	3	20
BLOOD_Myeloma	CDK1 →	+1.772	+0.107	<.001	.001	3	20
BLOOD_Myeloma	ZWILCH →	+1.252	+0.121	.001	.002	3	20
UPPER_AERODIGESTIVE_TRACT	FANCB →	+1.252	+0.139	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007088 vs MELK — OESOPHAGUS

Explore this scatter interactively →