Mitotic metaphase chromosome alignment

Across TCGA patient cohorts, RNA activity of the Mitotic metaphase chromosome alignment pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL12_S38, SMC2, and SMC4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic metaphase chromosome alignment activity versus RPL12_S38 in LUAD (Pearson r = 0.70).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL12_S38 →	+1.398	+0.130	<.001	<.001	3	10
GBM	SMC2 →	+0.782	+0.118	<.001	<.001	3	10
LUAD	SMC4 →	+0.738	+0.146	<.001	<.001	3	10
LUAD	TRIP13 →	+1.053	+0.128	<.001	<.001	3	10
LUAD	CDC20_T70 →	+1.401	+0.147	<.001	<.001	3	10
LUAD	CDK1 →	+1.065	+0.144	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007080 vs RPL12_S38 — LUAD

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