Mitotic nuclear membrane disassembly

Across TCGA patient cohorts, RNA activity of the Mitotic nuclear membrane disassembly pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CARMIL2_S991, PIK3CD, and SMC2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic nuclear membrane disassembly activity versus CARMIL2_S991 in OV (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CARMIL2_S991 →	+0.694	+0.102	.006	<.001	3	7
BRCA	PIK3CD →	+0.360	+0.060	.002	<.001	3	7
UCEC	SMC2 →	+0.587	+0.080	<.001	<.001	3	7
UCEC	SMC4 →	+0.528	+0.083	<.001	<.001	3	7
CCRCC	ZAP70 →	+0.393	+0.069	<.001	<.001	3	7
CCRCC	GMIP →	+0.399	+0.087	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007077 vs CARMIL2_S991 — OV

Explore this scatter interactively →