Mitotic sister chromatid cohesion

Across TCGA patient cohorts, RNA activity of the Mitotic sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VRK1, HELLS, and LYVE1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic sister chromatid cohesion activity versus VRK1 in LSCC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	VRK1 →	+0.782	+0.241	<.001	<.001	3	6
GBM	HELLS →	+0.964	+1.466	<.001	<.001	3	6
GBM	LYVE1 →	-1.426	-1.045	<.001	<.001	3	6
OV	CENPH →	+0.785	+0.689	<.001	.007	3	6
GBM	SKA3 →	+0.861	+0.687	<.001	<.001	3	6
GBM	MIR223HG →	-0.989	-1.228	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007064 vs VRK1 — LSCC

Explore this scatter interactively →