Sister chromatid cohesion

Across TCGA patient cohorts, RNA activity of the Sister chromatid cohesion pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC2, RFC3, and RFC4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sister chromatid cohesion activity versus RFC2 in UCEC (Pearson r = 0.66).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RFC2 →	+0.406	+0.117	<.001	<.001	3	9
UCEC	RFC3 →	+0.387	+0.088	<.001	<.001	3	9
UCEC	RFC4 →	+0.449	+0.100	<.001	<.001	3	9
LUAD	RPL12_S38 →	+1.285	+0.061	<.001	<.001	3	9
LUAD	RRM2 →	+0.892	+0.067	<.001	<.001	3	9
LUAD	RRM2_S20 →	+1.491	+0.065	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007062 vs RFC2 — UCEC

Explore this scatter interactively →