Sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MLPH, SPINDOC, and SKP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sister chromatid cohesion activity versus MLPH in BREAST (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MLPH →	-2.577	-0.223	.001	.001	3	6
BLOOD_Leukemia	SPINDOC →	+0.851	+0.204	.001	<.001	3	6
BLOOD_Leukemia	SKP2 →	+1.065	+0.321	<.001	<.001	3	5
BLOOD_Myeloma	DIMT1 →	-0.810	-0.225	.001	<.001	3	5
BONE	ELOVL1 →	-0.954	-0.309	.004	.008	3	5
STOMACH	LONRF3 →	-1.444	-0.220	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007062 vs MLPH — BREAST

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