Spindle assembly involved in female meiosis

Across TCGA patient cohorts, RNA activity of the Spindle assembly involved in female meiosis pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD3G, SLAMF6, and CD48, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spindle assembly involved in female meiosis activity versus CD3G in PDAC (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CD3G →	+0.732	+0.468	<.001	<.001	3	7
PDAC	SLAMF6 →	+0.938	+0.385	<.001	<.001	3	7
PDAC	CD48 →	+0.577	+0.285	<.001	.002	3	7
BRCA	PLA2G2D →	+1.326	+0.228	<.001	.001	3	6
BRCA	CD2 →	+1.234	+0.244	<.001	<.001	3	6
BRCA	CD8A →	+0.999	+0.235	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007056 vs CD3G — PDAC

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